Monocyte chemoattractant protein-1 is not required for liver regeneration after partial hepatectomy

TWEAK/Fn14 Signaling Is Required for Liver Regeneration after Partial Hepatectomy in Mice

BACKGROUND & AIMS Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis (TWEAK), is induced rapidly after PH and remains elevated throughout the period of peak hepatocyte replication. The role of Fn14 in post-PH liver regeneration is uncertain...

Regeneration of mouse liver after partial hepatectomy.

The rapidly growing liver tissue after partial hepatectomy has been used advantageously by in vestigators to study changes during accelerated growth and proliferation of cells (4, 7, 12, 15). Previous reports have been chiefly on rats. In many instances, pooled samples were taken for chemical data. In the present investigation a com prehensive study was made on individual samples of regeneratin...

Silymarin Accelerates Liver Regeneration after Partial Hepatectomy

Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and ...

Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1.

Monocyte chemoattractant protein 1 (MCP-1) has an important influence on monocyte migration into sites of inflammation. Our understanding of the signal transduction pathways involved in the response of monocytes to MCP-1 is quite limited yet potentially significant for understanding and manipulating the inflammatory response. Prior studies have demonstrated a crucial regulatory role for cytosol...

Monocyte Chemoattractant Protein 1 Required for Human Monocyte Chemotaxis Is 2 Calcium - Independent Phospholipase A